EWAS-PGC-PTSDsmallThe necessary but not sufficient role of the environment in PTSD development has led scientists to research the role of epigenetic modification. Epigenome-wide association studies (EWAS) of PTSD have provided replicable discoveries but have been modestly sized.

The Psychiatric Genetics Consortium (PGC) PTSD-EWAS working group will facilitate a multi-site EWAS of PTSD subjects and trauma-exposed controls. This highly collaborative working group currently includes over 20 investigators from all over the world and samples with methylome data of >1,700 subjects.

Caroline Nievergelt, Alicia Smith, Monica Uddin, and Mark Logue.
PI in person meeting over beignets at Cafe du Monde during the ISTSS (International Society for Traumatic Stress Studies) in New Orleans (Nov. 5-7 2015).